“Antibacterial Activity of Olive Oil Against Salmonella Typhi.”

Nailatul Fauziyah, Rachmat Faisal Syamsu, Yani Sodiqah, Marzelina Karim, Abdul Mubdi Ardiansar Arifuddin Karim

Abstract


Salmonella typhi merupakan penyebab utama demam tifoid yang sering memerlukan pengobatan antibiotik, namun masalah resistensi bakteri terhadap antibiotik menjadi tantangan besar dalam pengobatan. Penelitian ini bertujuan untuk menguji efek antimikroba dari tiga jenis minyak zaitun: Extra Virgin Olive Oil (EVOO), Extra Light Olive Oil (ELOO), dan Olive Pomace Oil (OPO) terhadap pertumbuhan Salmonella typhi. Metode yang digunakan adalah uji difusi cakram selama tiga hari di Laboratorium UP3M Fakultas Kedokteran Universitas Muslim Indonesia. Hasil penelitian menunjukkan bahwa ketiga jenis minyak zaitun menunjukkan zona hambat terbatas antara 7,0 mm hingga 9,0 mm, yang semuanya dinilai “Resisten”, mengindikasikan efektivitasnya yang terbatas. Meskipun EVOO memiliki zona hambat rata-rata tertinggi (8,37 mm), tidak ada perbedaan signifikan antara ketiga jenis minyak zaitun maupun dengan Ciprofloxacin (kontrol positif) yang menunjukkan zona hambat sebesar 33 mm. Penelitian ini menyoroti pentingnya pengembangan terapi alternatif berbasis alami untuk mengatasi infeksi bakteri seperti Salmonella typhi, namun juga menekankan perlunya penelitian lebih lanjut untuk memahami potensi penuh minyak zaitun dan cara untuk meningkatkan efektivitasnya, termasuk modifikasi kimia atau pengolahan lebih lanjut.


Keywords


Salmonella typhi, Olive Oil, Antimicrobial, Bacterial Resistance, Ciprofloxacin

References


Verliani H, Hilmi IL, Salman S. Faktor Risiko Kejadian Demam Tifoid di Indonesia 2018–2022: Literature Review. JUKEJ J Kesehat Jompa. 2022;1(2):144–54.

Kurniawan DA, Apriliana E, Himayani R. Faktor Risiko Personal dan Lingkungan dalam Kejadian Demam Tifoid Personal and Environmental Risk Factors in The Incidence of Typhoid Fever. Medula. 2025;14(11):2090–5.

Sharacel D, Setyawan FEB, Pratama P, Fauziah IF. Gambaran Faktor Resiko Hygiene Terhadap Demam Tifoid. CoMPHI J Community Med Public Heal Indones J [Internet]. 2023 Dec 14;4(1):68–73. Available from: http://comphi.sinergis.org/comphi/article/view/142

Sukma R, Indriputri C, Salam J. Uji Resistensi Salmonella typhi dari Penderita Demam Tifoid terhadap Beberapa Antibiotik. Cokroaminoto J Biol Sci [Internet]. 2023;5(1):1–7. Available from: https://science.e-journal.my.id/cjbs/article/view/137/124

World Health Organization. Quality Health Services: A Planning Guide [Internet]. World Health Organization; 2020. Available from: https://www.who.int/publications/i/item/9789240011632

Arfani N, Ka’bah K, Habibah H. Uji Sensitivitas Salmonella typhi terhadap Antibiotik Sefalosporin Generasi Ketiga pada Penderita Demam Tifoid. J-HEST J Heal Educ Econ Sci Technol. 2022;3(2):88–95.

Salam N, Said A, Ridwan BA. Identifikasi Drug Related Problems (DRPs) Pada Pasien Demam Tifoid di RSUD Kota Kendari Periode Januari-Desember 2020. J Pharm Mandala Waluya. 2022;1(2):83–93.

Sanjaya DA, Meriyani H, Juanita RA, Siada NB. Kajian Literatur: Profil Resistensi Salmonella typhi dan Pemilihan Antibiotik Pada Demam Tifoid. JPSCR J Pharm Sci Clin Res. 2022;7(2):107.

Hamdulay K, Rawekar R, Tayade A, Kumar S, Acharya S. Evolving Epidemiology and Antibiotic Resistance in Enteric Fever: A Comprehensive Review. Cureus [Internet]. 2024 Jun 24;16(6):e63070. Available from: https://www.cureus.com/articles/261280-evolving-epidemiology-and-antibiotic-resistance-in-enteric-fever-a-comprehensive-review

Bakhat S, Nadeem S, Hussain A, Sarwar S, Hussain B, Faheem F. Extensively Drug Resistant (XDR) Salmonella Typhi Red Flag For Clinicians at Karachi. Infect Dis J Pakistan [Internet]. 2023 Dec 28;32(4):138–42. Available from: https://ojs.idj.org.pk/index.php/Files/article/view/253

Akhtar R, Kismat S, Afroz F, Setu SK, Anwar S, Ahmed S. Antimicrobial Susceptibility Pattern of Multidrug Resistant Typhoidal Salmonella Isolates at Bangabandhu Sheikh Mujib Medical University. Bangladesh J Med Microbiol [Internet]. 2021 Jul 31;15(2):19–22. Available from: https://www.banglajol.info/index.php/BJMM/article/view/57816

Umair M, Siddiqui SA. Antibiotic Susceptibility Patterns of Salmonella Typhi and Salmonella Paratyphi in a Tertiary Care Hospital in Islamabad. Cureus [Internet]. 2020 Sep 3;12(9):e10228. Available from: https://www.cureus.com/articles/37058-antibiotic-susceptibility-patterns-of-salmonella-typhi-and-salmonella-paratyphi-in-a-tertiary-care-hospital-in-islamabad

Jimenez-Lopez C, Carpena M, Lourenço-Lopes C, Gallardo-Gomez M, Lorenzo JM, Barba FJ, et al. Bioactive Compounds and Quality of Extra Virgin Olive Oil. Foods [Internet]. 2020 Jul 28;9(8):1014. Available from: https://www.mdpi.com/2304-8158/9/8/1014

Romani A, Ieri F, Urciuoli S, Noce A, Marrone G, Nediani C, et al. Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L. Nutrients [Internet]. 2019 Aug 1;11(8):1776. Available from: https://www.mdpi.com/2072-6643/11/8/1776

Nazzaro F, Fratianni F, Cozzolino R, Martignetti A, Malorni L, De Feo V, et al. Antibacterial Activity of Three Extra Virgin Olive Oils of the Campania Region, Southern Italy, Related to Their Polyphenol Content and Composition. Microorganisms [Internet]. 2019 Sep 5;7(9):321. Available from: https://www.mdpi.com/2076-2607/7/9/321

Rebollada-Merino A, Ugarte-Ruiz M, Hernández M, Miguela-Villoldo P, Abad D, Rodríguez-Lázaro D, et al. Reduction of Salmonella Typhimurium Cecal Colonisation and Improvement of Intestinal Health in Broilers Supplemented with Fermented Defatted ‘Alperujo’, an Olive Oil By-Product. Animals [Internet]. 2020 Oct 21;10(10):1931. Available from: https://www.mdpi.com/2076-2615/10/10/1931

Cádiz-Gurrea M de la L, Pinto D, Delerue-Matos C, Rodrigues F. Olive Fruit and Leaf Wastes as Bioactive Ingredients for Cosmetics A Preliminary Study. Antioxidants [Internet]. 2021 Feb 5;10(2):245. Available from: https://www.mdpi.com/2076-3921/10/2/245

Agnesia Y, Sari SW, Nu’man H, Ramadhani DW, Nopianto. Buku Ajar Metode Penelitian Kesehatan. Pekalongan: Penerbit NEM; 2023.

Liberty IA. Metode Penelitian Kesehatan. Pekalongan: Penerbit NEM; 2024. 27–35 p.

Hardani, Andriani H, Utami EF, Fardani RA, Sukmana DJ, Auliya NH, et al. Buku Metode Penelitian Kualitatif dan Kuantitatif. Cetakan 1. Abadi H, editor. Yogyakarta: CV. Pustaka Ilmu Group Yogyakarta; 2020. 245 p.

Puxeddu S, Scano A, Scorciapino MA, Delogu I, Vascellari S, Ennas G, et al. Physico-Chemical Investigation and Antimicrobial Efficacy of Ozonated Oils: The Case Study of Commercial Ozonated Olive and Sunflower Seed Refined Oils. Molecules [Internet]. 2024 Feb 1;29(3):679. Available from: https://www.mdpi.com/1420-3049/29/3/679

Švarcová K, Hofmeisterová L, Švecová B, Šilha D. In Vitro Activity of Water Extracts of Olive Oil against Planktonic Cells and Biofilm Formation of Arcobacter-like Species. Molecules [Internet]. 2022 Jul 14;27(14):4509. Available from: https://www.mdpi.com/1420-3049/27/14/4509

Radzimierska-Ka?mierczak M, ?migielski K, Sikora M, Nowak A, Pluci?ska A, Kunicka-Styczy?ska A, et al. Olive Oil with Ozone-Modified Properties and Its Application. Molecules [Internet]. 2021 May 21;26(11):3074. Available from: https://www.mdpi.com/1420-3049/26/11/3074

Derakhshandeh?Rishehri S, Kazemi A, Shim SR, Lotfi M, Mohabati S, Nouri M, et al. Effect of Olive Oil Phenols on Oxidative Stress Biomarkers: A Systematic Review and Dose–Response Meta?Analysis of Randomized Clinical Trials. Food Sci Nutr [Internet]. 2023 May 13;11(5):2393–402. Available from: https://onlinelibrary.wiley.com/doi/10.1002/fsn3.3251

Marchello CS, Carr SD, Crump JA. A Systematic Review on Antimicrobial Resistance among Salmonella Typhi Worldwide. Am J Trop Med Hyg [Internet]. 2020 Dec 2;103(6):2518–27. Available from: https://ajtmh.org/doi/10.4269/ajtmh.20-0258

Saxena S, Kaur R, Randhawa VS. Changing Pattern of Resistance in Typhoid Fever in An Era of Antimicrobial Resistance: Is it Time to Revisit Treatment Strategies? J Microbiol Infect Dis [Internet]. 2021 Mar 15;11(1):1–7. Available from: https://www.jmidonline.org/?mno=302657161

Wang X, Biswas S, Paudyal N, Pan H, Li X, Fang W, et al. Antibiotic Resistance in Salmonella Typhimurium Isolates Recovered From the Food Chain Through National Antimicrobial Resistance Monitoring System Between 1996 and 2016. Front Microbiol [Internet]. 2019 May 7;10:985. Available from: https://www.frontiersin.org/article/10.3389/fmicb.2019.00985/full

Mylona E, Voong Vinh P, Qureshi S, Karkey A, Dongol S, Ha Thanh T, et al. Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi. J Antimicrob Chemother [Internet]. 2021 Nov 12;76(12):3197–200. Available from: https://academic.oup.com/jac/article/76/12/3197/6371920

Nwosu UO, Ibiam FA, Amadi-Ibiam CO, Aniokete UC, Iroha CS, Peter IU, et al. Antimicrobial Resistance Profile of Salmonella enterica Serovar typhi Isolated from Human Clinical Samples in Ebonyi State, Nigeria. J Adv Med Pharm Sci [Internet]. 2023 Oct 5;25(9):11–7. Available from: https://journaljamps.com/index.php/JAMPS/article/view/639

Muteeb G, Rehman MT, Shahwan M, Aatif M. Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review. Pharmaceuticals [Internet]. 2023 Nov 15;16(11):1615. Available from: https://www.mdpi.com/1424-8247/16/11/1615




DOI: https://doi.org/10.32502/sm.v16i2.10374

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Copyright (c) 2026 Nailatul Fauziyah, Rachmat Faisal Syamsu, Yani Sodiqah, Marzelina Karim, Abdul Mubdi Ardiansar Arifuddin Karim

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