Comparative Effects of Electric and Coil Mosquito Repellents on Mice (Mus musculus L)

Miranti Dwi Hartanti, Thia Prameswarie, Rury Tiara Oktariza, Amrizal Amrizal, Raden Ayu Tanzila, Liza Chairani, Afina Rasaki Asri

Abstract


Antinyamuk seperti elektrik, bakar, dan bentuk lainnya banyak digunakan meskipun diketahui memiliki risiko kesehatan yang cukup tinggi. Penelitian terbaru menunjukkan bahwa antinyamuk ini dapat bersifat toksik bagi paru-paru, namun data perbandingannya masih terbatas. Penelitian ini mengevaluasi efek antinyamuk elektrik dan bakar terhadap jaringan paru-paru serta parameter kimia darah pada mencit (Mus musculus L.). Tiga puluh mencit Swiss Webster diberikan perlakuan terhadap salah satu jenis antinyamuk tersebut selama 6 atau 8 jam setiap hari (n=6 per kelompok). Jaringan paru-paru diperiksa menggunakan pewarnaan H&E untuk menilai ketebalan septum alveolar dan infiltrasi sel imun, sementara kadar low-density lipoprotein (LDL) dan high-density lipoprotein (HDL) diukur dari sampel darah. Uji statistik meliputi uji Shapiro-Wilk, uji Levene, ANOVA, dan uji post hoc Tukey HSD (p < 0,05). Kedua antinyamuk secara signifikan meningkatkan ketebalan septum alveolar (antinyamuk bakar: 32,45±10,52 µm; antinyamuk elektrik: 24,87±8,76 µm pada 8 jam; p<0,001 dibandingkan kontrol: 22,34±9,87 µm) dan menyebabkan dislipidemia (LDL: 148,23±5,76 mg/dL vs. 139,81±7,61 mg/dL; HDL: 11,46±8,21 mg/dL vs. 14,46±5,64 mg/dL). Antinyamuk bakar menunjukkan tingkat toksisitas yang lebih tinggi (p=0,001), kemungkinan akibat emisi PAH. Temuan ini mengungkapkan adanya hubungan antara perubahan mikroskopis pada jaringan paru dan perubahan kimia darah pada mencit yang terpapar antinyamuk tersebut.

Keywords


mosquito repellent, pharmaco-toxicology, histopathology, pulmonary, alveolar septa

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DOI: https://doi.org/10.32502/sm.v16i1.11104

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Syifa Medika: Jurnal Kedokteran dan Kesehatan

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