Email this article KOEKSISTENSI KANKER PARU DAN TUBERKULOSIS
Abstract
ABSTRAK
Koeksistensi kanker paru dan tuberkulosis (TB) telah diketahui dalam banyak studi. Deskripsi tentang hubungan kanker paru dan TB pertama kali dilaporkan lebih dari 200 tahun lalu oleh Bayle pada tahun 1810 yang dikenal dengan “cavitation cancereuse”. Lebih dari sepertiga laporan kasus menyatakan terjadi misdiagnosis antara TB dan kanker paru pada presentasi klinis awal pasien. Proses inflamasi kronis pada TB menyebabkan peningkatan produksi sitokin yang menstimulasi pertumbuhan tumor dan progresifitas sel kanker. Sebaliknya deplesi sel imun, kondisi malnutrisi, dan efek dari pengobatan kemoterapi pada pasien kanker paru menyebabkan penurunan imunitas pasien yang meningkatkan risiko infeksi dan reaktivasi TB. Diagnosis dan pengobatan dari koeksistensi TB dan kanker paru masih menjadi tantangan terutama pada negara endemis.Pengobatan TB yang tidak menunjukkan perbaikan baik klinis maupun radiologis selama 5 minggu harus dicurigai sebagai kanker paru. Kemoterapi bukanlah kontraindikasi pada pemberian terapi obat anti tuberkulosis (OAT) secara bersamaan pada pasien dengan koeksistensi kanker paru dan TB. Evaluasi keberhasilan terapi antara lain adalah dengan menurunnya keluhan awal, perbaikan tampilan klinis, perbaikan radiologis, dan evaluasi efek samping pengobatan.
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Çakar B, Çileda? A. Evaluation of coexistence of cancer and active tuberculosis; 16 case series. Respir Med Case Reports 2018;23(7):33–37.
Ho JC man, Leung CC. Management of co-existent tuberculosis and lung cancer. Lung Cancer [Internet] 2018;122:83–87. Available from: https://doi.org/10.1016/j.lungcan.2018.05.030
Falagas ME, Kouranos VD, Athanassa Z, Kopterides P. Tuberculosis and malignancy. Qjm 2010;103(7):461–487.
Koksal D, Kizilgoz D, Ozcan A, Safak Kosan O, Kalac N, Berkoglu M. Is Tuberculosis a Challenge in the Management of Lung Cancer? Eurasian J Pulmonol 2016;19(1):46–50.
Cheng MP, Chakra CNA, Yansouni CP, et al. risk of active tuberculosis in patients with cancer: A systematic review and metaanalysis. Clin Infect Dis 2017;64(5):635–644.
Argun Bar?? S, Batman A, Küçük S, Gümü?ta? S. Coexistence of pulmonary tuberculosis and sarcoidosis. Respir Case Reports 2017;6(2):86–89.
Liang HY, Li XL, Yu XS, et al. Facts and fiction of the relationship between preexisting tuberculosis and lung cancer risk: A systematic review. Int J Cancer 2009;125(12):2936–2944.
World Health Organization. Global TB Reports. 2018.
Kementrian Kesehatan Republik Indonesia. Pedoman Nasional Pelayanan Kedokteran Kanker Paru. 2017;
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin [Internet] 2018;68(6):394–424. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30207593
Pakzad R, Mohammadian-Hafshejani A, Ghoncheh M, Pakzad I, Salehiniya H. The incidence and mortality of lung cancer and their relationship to development in Asia. Transl Lung Cancer Res 2015;4(6):763–774. available on http://tlcr.amegroups.com/article/view/6148/5865
Rihawi A, Huang G, Al-Hajj A, Bootwala Z. A case of tuberculosis and adenocarcinoma coexisting in the same lung lobe. Int J Mycobacteriology 2016;5(1):80–82.
Cicenas S, Vencevi?ius V. Lung cancer in patients with tuberculosis. World J Surg Oncol 2007;5(1991):1–5.
O’Callaghan DS, O’Donnell D, O’Connell F, O’Byrne KJ. The role of inflammation in the pathogenesis of non-small cell lung cancer. J Thorac Oncol 2010;5(12):2024–2036
Harikrishna J, Sukaveni V, Kumar DP, Mohan A. Cancer and tuberculosis. Journal, Indian Acad Clin Med 2012;13(2):142–144.
Sunaga N, Kaira K. Epiregulin as a therapeutic target in non-small-cell lung cancer. Lung Cancer Targets Ther 2015;6(October):91–98.
Jacobs REA, Gu P, Chachoua A. Reactivation of pulmonary tuberculosis during cancer treatment. 2015;4(550):7–10.
Lee HY, Kim JW, Yeo CD. A case of tuberculosis reactivation suspected of cancer progression during oral tyrosine kinase inhibitor treatment in a patient diagnosed as non-small cell lung cancer. J Thorac Dis 2017;9(8):E709–E713.
D Gothi SS. Tuberculosis in epidermal growth factor receptor mutation in lung adenocarcinoma on treatment with gefitinib/erlotinib. Indian J Cancer 2017;54(1):1.
Anastasopoulou A, Ziogas DC, Samarkos M, Kirkwood JM, Gogas H. Reactivation of tuberculosis in cancer patients following administration of immune checkpoint inhibitors: Current evidence and clinical practice recommendations. J Immunother Cancer 2019;7(1).
Fujita K, Terashima T, Mio T. Anti-PD1 Antibody Treatment and the Development of Acute Pulmonary Tuberculosis. J Thorac Oncol [Internet] 2016;11(12):2238–2240. Available from: http://dx.doi.org/10.1016/j.jtho.2016.07.006
Singh VK, Chandra S, Kumar S, Pangtey G, Mohan A, Guleria R. RESEARCH COMMUNICATION A Common Medical Error : Lung Cancer Misdiagnosed as Sputum Negative Tuberculosis. Cancer 2009;10:335–338.
Aviani J, Eh SM, Haryatie I, Raharjo F, Sutanto YS, Setijadi AR. Keterlambatan Diagnosis Kanker Paru Karena Kesalahan Diagnosis Sebagai Tubekulosis Paru The Delay in The Diagnosis of Lung Cancer Due to Misdiagnosis as Pulmonary Tuberculosis. 2017;37(4):288–292.
Parker CS, Siracuse CG, Litle VR. Identifying lung cancer in patients with active pulmonary tuberculosis. 2018;10(Suppl 28):3392–3397.
Report C, Case R. Annals of Clinical Case Reports Coexistence of Lung Cancer and Primary Lymph Nodes Tuberculosis Diagnosed by Cancer Staging : A Report of a. 2016;1(Figure 2):7–9.
Hara T, Kosaka N, Suzuki T, Kudo K, Niino H. Uptake rates of 18 F-fluorodeoxyglucose and 11 C-choline in lung cancer and pulmonary tuberculosis: A positron emission tomography study. Chest [Internet] 2003;124(3):893–901. Available from: http://dx.doi.org/10.1378/chest.124.3.893
Fatmawati F. Kanker Paru. In: Amin M, editor. Buku Ajar Paru. Surabaya: Airlangga University Press; 2019. p. 125–143.
Sihoe ADL, Shiraishi Y, Yew WW. The current role of thoracic surgery in tuberculosis management. Respirology 2009;14(7):954–968.
S. E, V. B, L. A, et al. Management and Surgical Outcomes of Concurrent Tuberculosis and Lung Cancer. Thorac Cardiovasc Surg [Internet] 2017;65(7):542–545.
Fulkerson LL. Radiotherapy for Chest Cancers in Patients with Tuberculosis. Hosp Pract 1970;5(11):103–113.
Hirashima T, Tamura Y, Han Y, et al. Efficacy and safety of concurrent anti-Cancer and anti-tuberculosis chemotherapy in Cancer patients with active Mycobacterium tuberculosis: a retrospective study. BMC Cancer 2018;18(1):1–10. https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4889-1
Tan, Hui, Eng et al. Comparison of the clinical courses and chemotherapy outcomes in metastatic colorectal cancer patients with and without active Mycobacterium tuberculosis or Mycobacterium kansasii infection: a retrospective study. BMC Cancer [Internet] 2014;14(PG-770):770. Available from: NS -
Antonios Christopoulos. Anticancer chemotherapy combined with anti-tuberculosis treatment: A systematic review. Eur Respir J [Internet] 2013;42:no pagination.
Sculier J, Berghmans T, Meert A. Advances in target therapy in lung cancer. 2015;23–29. Available from: http://dx.doi.org/10.1183/09059180.00011014
Peters S, Zimmermann S, Adjei AA. Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer : Comparative pharmacokinetics and drug – drug interactions. Cancer Treat Rev [Internet] 2014;40(8):917–926. Available from: http://dx.doi.org/10.1016/j.ctrv.2014.06.010
Lee L, Cheung WY, Atkinson E, Krzyzanowska MK. Impact of comorbidity on chemotherapy use and outcomes in solid tumors: A systematic review. J Clin Oncol 2011;29(1):106–117.
DOI: https://doi.org/10.32502/sm.v11i1.2583
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