The Effect of Katuk Leaf Extract (Sauropus androgynus (L.) Merr.) Administration on the Libido of Male White Rats (Sprague Dawley)
Abstract
ABSTRACT
Low libido is one of the most common forms of sexual dysfunction among adult men and has a relatively high prevalence, including in Indonesia. The increasing public interest in herbal medicine has encouraged the use of katuk leaves (Sauropus androgynus (L.) Merr), which contain bioactive compounds such as saponins, alkaloids, and flavonoids that are presumed to possess aphrodisiac properties. This study aimed to evaluate the effect of katuk leaf extract on libido enhancement in male white rats. This study employed a true experimental design using a post-test with control group approach. The animals were divided into three groups, namely a negative control group receiving distilled water and standard feed, and two treatment groups receiving katuk leaf extract at doses of 100 mg/kgBW and 200 mg/kgBW, respectively. The extract was obtained through maceration using 96% ethanol. The observed parameters were the frequencies of introduction and climbing as indicators of libido-related behaviour. The analysis showed no statistically significant differences among the groups for the introduction parameter (p = 0.310) and the climbing parameter (p = 0.368). These findings indicate that administration of katuk leaf extract for 7 days did not significantly enhance libido. This outcome may have been influenced by several factors, including the absence of estrous phase screening in female rats, excessive cage lighting, and a possible reduction in bioactive compound content due to a suboptimal drying process. Previous studies reporting significant effects generally used longer treatment durations and stricter control of physiological conditions.
Keywords: Aphrodisiac, Libido, Sauropus androgynus (L.) Merr.
Keywords
Full Text:
PDFReferences
Daftar Pustaka
Shigehara K, Kato Y, Iijima M, et al. Risk Factors Affecting Decreased Libido Among Middle-Aged to Elderly Men ; Nocturnal Voiding is an Independent Risk Factor of. Sex Med. 2021;9(5):100426. doi:10.1016/j.esxm.2021.100426
Corona G, Maggi M. The role of testosterone in male sexual function MetS Metabolic syndrome. Rev Endocr Metab Disord. 2022;(August):1159-1172. doi:10.1007/s11154-022-09748-3
Herkommer K, Meissner VH, Dinkel A, et al. Prevalence , lifestyle , and risk factors of erectile dysfunction , premature ejaculation , and low libido in middle-aged men : first results of the Bavarian Men ’ s Health-Study. Andrology. 2024;(July 2023):801-808. doi:10.1111/andr.13524
Sinuraya L, Hidayari R, Murti B. Hubungan antara Aktivitas Fisik dengan Libido Seksual pada Pria. NEXUS KEDOKTERAN KOMUNITAS VOL3./NO.2/DESEMBER/2014 produksi2014;3(2):142-150.
Putri CA, Lubis M. Pengaruh Pemberian Ekstrak Etanol 90% Daun Kelor (Moringa oleifera) Terhadap Libido Tikus Jantan. JURNAL ILMIAH KOHESI. 2023;7.4: 271-274.
WHO. Traditional medicine in the South-East Asia. www.WHO.com. Published 2024. Accessed November 3, 2024. https://www.who.int/southeastasia/health-topics/traditional-complementary-and-integrative-medicine
Rusdi NK, Putu N, Hikmawanti E, Ulfah YS. Aktivitas Afrodisiaka Fraksi dari Ekstrak Etanol 70 % Daun Katuk ( Sauropus androgynus ( L ). Merr ) Pada Tikus Putih Jantan Aphrodisiac Activity of 70 % Ethanol Extract Fraction of Katuk Leaves ( Sauropus androgynus ( L ). Merr ) in The Male White Rat. Pharmaceutical Sciences and Research. 2018;5(August):123-132.
Santoso H, Zen S. Bioporeksi Tanaman Aphrodisiak Indonesia. Hasil Penelitian AH. 2 1*,2. Prosiding SNPPM-5 Universitas Metro. 2023;5:64-81.
Kurniawan H, Dillasamola D, Rumapea R. Uji Afrodisiak Daun Katuk (Sauropus androgynus (L). merr) Pada Mencit (Mus muscullusL) Obesitas. SCIENTIA Jurnal Farmasi dan Kesehatan. 2020;10(2):235-242.
Andayani D, Arlita D, Diarti W, Magdalena S, Yuwono B. Pengaruh Ekstrak Etanol 96 % Daun Katuk ( Sauropus Androgynus ) Terhadap Waktu Perdarahan ( Bleeding Time) Pada Kelinci Putih Jantan ( Oryctolagus Cuniculus ). 2020;8(2):49-51.
Malini DM, Wulandari S. Perilaku Kawin Tikus (Rattus norvegicus) Jantan
Diabetes Yang Diberi Ekstrak Etanol Kulit Buah Jengkol (Archidendron pauciflorum) Mating Behavior In Male Rat (Rattus Norvegicus) Diabetic that Given Ethanol Extract Of Jengkol (Archidendron Pauciflorum) Fruit Peel. Journal of Biological Sciences. 2020;7(September):276-284. doi:10.24843/metamorfosa.2020.v07.i02.p17.
Budiawan A. Uji Aktivitas Afrodisiaka Infusa Kulit Buah Semangka ( Citrullus lanatus) Aphrodisiac Activity of Watermelon ( Citrullus lanatus ) Rind Infusion. Journal of Pharmaceutical Science and Medical Research. 2021;4(1):1-10.
Alfiraza EN, Listina O, Gautama TS. Efektivitas Afrodisiaka Kombinasi Ekstrak Buah Pare ( Momordica charantia L .) dan Bawang Putih ( Allium sativum L .) Pada Mencit Putih ( Mus muscullus ) Jantan Effectiveness Of Combination Of Bitter Gourd ( Momordica charantia L .) and Garlic ( Allium sativum L .) Extract On Male White Mice ( Mus muscullus ) As Aphrodisiac. Jurnal Farmasi. 2022;5(1).
Hasaaanah IW. Pengaruh Ekstrak Daun Pegagan( Centella asiatica) Terhadap Spermatogenesis Mencit (Mus musculus). Skripsi: Jurusan Biologi, Universitas Islam Negeri Maulana Malik Ibrahim. Malang; 2009;(05520023).
Sarapi VA, Widdhi B, Gayatri C. Uji Efek Afrodisiak Ekstrak Etanol Buah Pare (Momordica charantia L.) Terhadap Libido Tikus Putih Jantan Galur Wistar (Rattus norvegicus). Jurnal Ilmiah Farmasi. 2015.
Ajayi AF. Staging of the estrous cycle and induction of estrus in experimental rodents : an update. Fertility Research and Practice. 2020;3:1-15. https://doi.org/10.1186/s40738-020-00074-3.
Tambalean FE, Tombuku JL, Datu OS, Paat VI. Pengaruh Pemberian Etinil Estradiol Terhadap Perubahan Histologi Uterus Tikus Putih (Rattus norvegicus). Majalah InfoSains. 2021;2(1):13-26.
Faradisa RN. Efektivitas Kombinasi Ekstrak Tapak Liman (Elephantopus Scaber) Dan Daun Katuk (Sauropus Androgynus) Terhadap Kadar Hormon LH, FSH, Dan Prolaktin Mencit Bunting Yang Terinfeksi E.Coli. Universitas Brawijaya. 2018.
Pratomo, H. Peningkatan Libido Dan Populasi Sel Basofil Hipofisis Tikus Jantan Putih Pengaruh Pemberian Pasak Bumi. Prosiding Seminar Nasional Matematika, Sains, dan Teknologi. 2013.
Rizaldi A, Soebadi DM, Seotojo S. The Effect Of Chronic Exposure Of Nicotine Inhalation To The Count Of Spermatogonia, Sertoli Cells And Leydig Cells Of Young White Rat Wistar Strain. Indonesian Journal Of Urology. 2019. doi: https://doi.org/10.32421/juri.v26i2.512
Arifien A. Uji Efek Seduhan Daun Katuk (Sauropus androgynus (L.) Merr) Terhadap Libido Tikus Jantan (Rattus novergicus) Dalam Penggunaannya Sebagai Afrodisiak Dengan Alat Libidometer. Jurnal Ilmiah Mahasiswa Universitas Surabaya. 2013;2(1).
Frianto F, Fajriaty I, Riza H. Evaluasi Faktor Yang Mempengaruhi Jumlah Perkawinan Tikus Putih (Rattus novergicus) Secara Kualitatif. Jurnal Farmasi Kalbar. 2015.
Jiang D li, Xu Y long, Pan J qiu, Fan D, Shen X, Li W yan. Effects of melatonin on testicular function in adult male mice under different photoperiods. Animal Reproduction. 2022;19(202102080162):1-11.
Indryastuti D. Kajian Efek Ekstrak Tumbuhan terkait Libido Mencit ( Mus musculus L .) Jantan. BioTeach: Biology Science and Biology Education Journal. 2025;02(01):11-22.
Adnan H, Hayder A hameed, Saloom F. The main causative factor of increased mortality rate in experimental rat. Multidisciplinary Science Journal. Published online 2024:1-10. https://doi.org/10.31893/multiscience.2024130.
Apsari, D, Aprilianto, MN, Desyani LN, Widayanti NP. Pengaruh Metode Pengeringan Terhadap Kadar Senaywa Bioaktif Dan Aktivitas Antioksidan Pada Herba Suruhan (Peperomia pellucida L.). Jurnal Ilmiah Ibnu Sina. 2021;6(2): 302-311.
DOI: https://doi.org/10.32502/msj.v6i2.10365
Refbacks
- There are currently no refbacks.
Copyright (c) 2026 Watsiqoh Anisti Harahap
Medical Scientific Journal (MESINA) indexed by :
Medical Scientific Journal (MESINA) Published by Faculty of Medicine, University of Muhammadiyah, Palembang, South Sumatra. This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
________________________________________________
Medical Scientific Journal (MESINA)
Faculty of Medicine, University of Muhammadiyah Palembang
Jl. KH. Balqi Jl. Banten II, 13 Ulu, Kec. Seberang Ulu II, Palembang City, South Sumatera 30263
E-Mail: mesina@um-palembang.ac.id