MANIFESTASI OKULAR PADA COVID-19

Indah Septiana; Vina Pramayastri

doi:10.32502/sm.v12i1.2981

MANIFESTASI OKULAR PADA COVID-19

Indah Septiana, Vina Pramayastri

Abstract

Pada awal tahun 2020 dunia dibuat gempar oleh wabah pneumonia dari Wuhan yang disebabkan oleh virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2) atau disebut COVID-19, dan dengan cepat menjadi pandemik di seluruh dunia. COVID-19 ditransmisikan melalui membran mukosa dan menginvasi sel penjamu melalui sel reseptor Angiotensin Converting Enzyme-2 (ACE-2) yang juga terdapat di konjungtiva, kornea dan cairan akuos. Meski manifestasi okular bukan merupakan gejala utama dari COVID-19 namun World Health Organization (WHO) melaporkan pasien COVID-19 dengan kongesti konjungtiva. Beberapa jurnal juga melaporkan manifestasi okular, seperti konjungtivitis pada pasien COVID-19 dengan atau tanpa nilai positif pada pemeriksaan polymerase chain reaction (PCR) spesimen mata.

Keywords

COVID-19, manifestasi okular, konjungtivitis

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References

World Health Organization. Novel Coronavirus ( 2019-nCoV ) Situation Report - 1

January 2020. (Online) 21 Januri 2021 di https://apps.who.int/iris/handle/10665/330760. [diakses tanggal 20 Juli 2020].

Nguyen M, Zhang Y, Pandolfi P, Chen Y, Mao L, Nassis P, et al. 2020. Return of the Coronavirus: 2019-nCoV. Lancet. 9(20):2019–20.

Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, et al. 2020. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci. 63(3):457–60.

Xia J, Tong J, Liu M, Shen Y, Guo D. 2020. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol. 92(6):589-594.

Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, et al. 2020. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2019:5–8.

Loon SC, Teoh SCB, Oon LLE, Se-Thoe SY, Ling AE, Leo YS, et al. 2004. The severe acute respiratory syndrome coronavirus in tears. Br J Ophthalmol. 88(7):861–3.

World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). (Online) 16-24 Februari 2020 di https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf. [diakses 18 februari 2020].

Lu CW, Liu XF, Jia ZF. 2020. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet. 395(10224):e39.

World Health Organization. Corona Virus Disease 2019 (COVID-19) : Situation Report-17. (Online) 22 Juli 2020 di https://www.who.int/docs/defaultsource/searo/indonesia/covid19/external-situation-report-17-21july2020.pdf?sfvrsn=e15ee803_2. [diakses 22 Juli 2020].

Van Doremalen N, Bushmaker T, Morris DH, Hoolbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI, et al. 2020. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 382(16):1564-1567.

Li JO, Lam DSC, Chen Y, Ting DSW. 2020. Novel Coronavirus disease 2019 (COVID-19): The importance of recognising possible early ocular manifestation and using protective eyewear. Br J Ophthalmol. 104(3):297-298.

Sun Y, Pan X, Liu L, Al. E. 2004. Expression of SARS-CoV S protein functional receptor ACE2 in human and rabbit cornea and conjunctiva. New Adv Ophthalmol. 24(5):332–6.

Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, et al. 2020. Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study. Acta Ophtalmologica. 98(8):e951-e959.

American Academy of Ophthalmology. Eye Care During the Coronavirus Pandemic. (Online) Mei 2020 di https://www.aao.org/eye-health/tips-prevention/coronavirus-covid19-eye-infection-pinkeye. [diakses pada 28 Mei 2020].

Yeo C, Kaushal S, Yeo D. 2020. Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?. Lancet Gastroenterol Hepatol. 5(4):335–7.

Raboud J, Shigayeva A, McGeer A, Bontovics E, Chapman M, Gravel D, et al. 2010. Risk factors for SARS transmission from patients requiring intubation: A multicentre investigation in Toronto, Canada. PLoS One. 5(5):e10717.

Zhang X, Chen X, Chen L et al. 2020. The infection evidence of SARS-COV-2 in ocular surface study. Ocul Surf. 18(3);360-362.

Zhou Y, Zeng Y, Tong Y. 2020. Ophthalmologic Evidence Againts The Interpersonal Transmission of 2019 Novel Coronavirus Through Conjungtiva. medRxiv Prepr. 1(2):1–4.

Seah I, Agrawal R. 2020. Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals. Ocul Immunol Inflamm. 28(3):391–395.

Khavandi S, Tabibzadeh E, Naderan M, Shoar S. 2020. Corona virus disease-19 (COVID-19) presenting as conjunctivitis: atypically high-risk during a pandemic. Cont Lens Anterior Eye. 43(3):211-212.

Cheema M, Aghazadeh H, Nazarali S, Ting A, Hodges J, McFarlane A, et al. 2020. Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19). Can J Ophthalmol. 2019:1–5.

Daruich A, Martin D, Bremond-Gignac D. 2020. Ocular manifestation as first sign of Coronavirus Disease 2019 (COVID-19): Interest of telemedicine during the pandemic context. J Fr Ophtalmol. 43(5):389–91.

Navel V, Chiambaretta F, Dutheil F. Haemorrhagic conjunctivitis with pseudomembranous related to SARS-CoV-2. Am J Ophthalmol Case Reports. 19(5):100735.

DOI: https://doi.org/10.32502/sm.v12i1.2981